Coenzyme Q10, also known as ubiquinone, is a naturally occurring antioxidant found in the cells of the body. It plays a crucial role in the production of adenosine triphosphate (ATP), the energy currency of cells. This process helps convert nutrients into usable energy.

In addition to its energy production role, Coenzyme Q10 helps protect cells from oxidative stress by neutralising free radicals. This dual function makes it important for overall cellular health and has led to coenzyme use in dietary supplements in many countries. However, it is recommended to consult a doctor before incorporating CoQ10 as a dietary supplement. 

 

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Benefits of CoQ10

Subsides the Effects of Chemotherapy 

According to a 2002 study published by the National Cancer Institute, USA, coenzyme Q10 has shown an ability to stimulate the immune system and to protect the heart from anthracycline-induced cardiotoxicity (anthracyclines are a family of chemotherapy drugs, including doxorubicin, that have the potential to damage the heart).

Some research indicates that CoQ10 supplementation may help alleviate the side effects associated with chemotherapy, such as fatigue and muscle weakness, thereby supporting overall well-being during treatment. 

 

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Optimises Cellular Energy Production 

Coenzyme Q10 is also involved in regulating key enzymes that influence energy metabolism, further enhancing its role in cellular energy production. 

According to the 2008 research published in the Journal of the International Society of Sports Nutrition, the adequate levels of CoQ10 may improve exercise performance and endurance by ensuring that muscles receive a consistent energy supply. 

Moreover, It also serves as an antioxidant to protect cells against oxidative stress.This protective role is particularly important as oxidative stress is linked to various age-related diseases and conditions.

 

May Help Treat Heart Failure 

A 2020 review of Cochrane Database System suggests that CoQ10 might help manage heart failure when used with other treatments, but more studies are needed. 

The research indicates that people with heart failure who took CoQ10 supplements had a lower risk of death or hospitalisation and showed better improvement in heart function compared to those who took a placebo.

 

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Helps with Fertility Issues 

As women age, fertility declines due to a decrease in both the number and quality of eggs. CoQ10 plays a role in this process, as its production slows down with age, making it harder for the body to protect eggs from oxidative damage. 

According to a 2021 study published by the International Journal of Molecular Sciences, taking CoQ10 supplements may help preserve egg quality and counteract the age-related decline in egg quantity and quality.

Men's fertility can also be affected by oxidative damage, leading to lower sperm counts, reduced sperm quality, and infertility. Several studies indicate that CoQ10 supplementation may enhance sperm activity and concentration by boosting antioxidant protection.

 

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Natural Sources of CoQ10

The daily requirement of CoQ10, both from endogenous biosynthesis (internally) and from dietary sources, is approximately 500 mg.

CoQ10 is found throughout the body. About half of the body's Coenzyme Q10 is acquired through diet, while the rest is produced internally. Major dietary sources include meats, fish, such as salmon and sardines, pork, chicken, nuts, soybeans, and vegetable oils. Other foods, though containing lower amounts of CoQ10, include dairy products, vegetables, fruits, and cereals.

A 2002 study published by the National Cancer Institute, USA CoQ10 production decreases as you age. Thus, older people can be deficient in this compound.
Possible causes of low CoQ10 levels include:

• Genetic defects in how the body creates and uses CoQ10
• Increased demands by tissues as a consequence of disease
• Mitochondrial diseases
• Oxidative stress due to ageing
• Side effects of statin treatments.

 

Where is Coenzyme CoQ10 Present?

Coenzyme CoQ10 is present in most tissues, but the highest concentrations are found in heart, liver, kidneys and pancreas. If you are taking in a supplement form then consider consuming food along with it because CoQ10 is a fat-soluble compound, its absorption is slow and limited. However, taking CoQ10 supplements with food can help your body absorb it better.

 

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Downsides of CoQ10

While CoQ10 is generally well-tolerated, some individuals may experience mild side effects. Common side effects can include: 
Possible mild gastrointestinal issues:

• Nausea
• Diarrhea
• Stomach upset

 

Other potential side effects:

• Headaches
• Dizziness
• Fatigue
• Rare allergic reactions, which may include:
• Rash
• Itching

 

May interact with certain medications, such as:

• Blood thinners
• Diabetes medications

 

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