The current talk of the wellness town is NAD IV drips for anti-ageing. NAD+ IV drips are becoming the go-to biohacking tools for enhanced energy, anti-ageing, better focus, stamina, and improving overall health. Celebrities, athletes, and wellness enthusiasts are swearing by these infusions. This therapy is the secret to Soha Ali Khan, Jhanvi Kapoor, Arjun Kapoor, Kendall Jenner and Hailey Bieber's health and youthfulness. 

 

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In an informative YouTube podcast featuring Andrew Huberman, Dr. Peter Attia, M.D., a renowned physician trained at Stanford and Johns Hopkins School of Medicine, discusses the NAD pathway in human cells. He confidently explores its significant connections to ageing and health, shedding light on how it can enhance human healthspan and lifespan.

 

NAD And Its Impact on Ageing

Nicotinamide adenine dinucleotide (NAD+) is a vital molecule found in all living cells, playing a key role in essential biological functions. In simple terms, NAD+ helps convert nutrients from our food into usable energy, powering cellular functions.​ Chronic inflammation, often prevalent in the elderly, leads to the activation of immune responses that consume substantial amounts of NAD⁺. A 2022 report in Frontiers in Endocrinology shows elevated activity of NAD⁺ consuming enzymes, such as poly(ADP-ribose) polymerases (PARPs) and CD38, during inflammatory states accelerate NAD⁺ depletion. This reduction compromises cellular functions and worsens age-related pathologies. Besides, decline in NAD+ also reduces NAD⁺ biosynthesis which damages cellular metabolism and resilience to stress, contributing to the aging process. 

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How Do NAD+IV Drips Therapy Work?

NAD+ intravenous (IV) drip therapy is a method to replenish low NAD+ levels directly. This therapy involves administering NAD⁺ directly into the bloodstream, bypassing the digestive system to ensure maximum absorption and immediate availability to cells.​

A 2018 research cited in the Transational Medicine of Ageing suggests that increased NAD+ levels could slow down or even reverse some aspects of ageing while also may delay progression of chronic conditions. NAD+ IV therapy delivers this essential coenzyme directly into the bloodstream, bypassing the digestive system for faster and more effective absorption. This means your body can immediately use it to power up your cells, enhance metabolism, and support DNA repair. 

 

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Health Benefits of NAD+IV

Low levels of NAD+ levels may damage DNA due to things like pollution, stress, and natural wear and tear. Also, lower NAD⁺ availability in the body can lead to fatigue and reduced stamina, which is common as we age. In the podcast, Dr. Peter Attia explains the health benefits of NAD supplements. ​Nicotinamide Riboside (NR) and Nicotinamide Mononucleotide (NMN) are supplements that have gained attention for their potential to boost NAD+ levels, a crucial molecule involved in various cellular processes. 

 

Here are some potential advantages of using NAD supplements:

1. Improves Energy: By boosting NAD+ levels, NR and NMN may enhance mitochondrial function, leading to improved energy production. This boost in cellular energy donates vitality and endurance. ​
2. Repairs DNA: Administering NAD⁺ intravenously allows for rapid elevation of NAD⁺ concentrations in the bloodstream. Once in circulation, NAD⁺ can be taken up by cells, where it serves as a substrate (a surface on which an enzyme acts) for enzymes like poly (ADP-ribose) polymerases (PARPs), which are involved in detecting and repairing DNA damage.
3. Improves Metabolic Health: NR supplementation can positively influence metabolic health by enhancing glucose metabolism and insulin sensitivity. A 2023 research cited in the journal Molecule involving obese mice demonstrated that NR reduced weight gain and improved insulin sensitivity, suggesting potential benefits for metabolic disorders. ​ 
4. Reduces Inflammation: NR supplementation reduced inflammation in white adipose tissue and improved liver function, indicating a potential role in mitigating age-related inflammatory processes.
5. Backs Mitochondrial Health: NR supplementation also helps increase mitochondrial biogenesis and function, which are crucial for energy production and cellular health.
6. Potential Longevity Benefits: By supporting cellular repair mechanisms and metabolic functions, maintaining adequate NAD+ levels through supplementation may add to increased longevity.

 

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Who Can Go For NAD+ IV Therapy or Supplements?

• Anyone struggling with chronic fatigue and low energy levels can find renewed vigour through this therapy. 
• Individuals facing brain fog and memory challenges will experience a significant boost in cognitive clarity. 
• Those recovering from alcohol or substance use will receive vital support on their journey to wellness. 
• People seeking anti-aging and longevity benefits will discover powerful rejuvenation effects. 
• Individuals grappling with chronic diseases and metabolic issues will gain a crucial ally in their health management. 
• Athletes looking to enhance their performance and recovery will harness the superior benefits of NAD+ therapy.

 

Who Should Avoid NAD+IV Therpay or Supplements?

Certain groups should be careful or avoid NAD+ supplementation . It is advisable to consult an expert before going for this IV therapy:​

• Pregnant and Breastfeeding Women: Limited research exists on safety during pregnancy and lactation. ​So, it is only wise to avoid expecting women.
• Individuals with Cancer: Given NAD+'s role in cell metabolism, there are concerns about its effects on cancer cell growth. ​

 

Common Side Effects of NAD+IV Drips

NAD+ may be known for its potential anti-aging and health-enhancing properties. However, it's essential to be aware of possible risks and side effects associated with its supplementation.​

• Nausea and Digestive Issues
• Headaches and Fatigue
• Skin Reactions
• Liver Health
• Changes in Blood Pressure

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NAD⁺ IV drip therapy offers an innovative solution for counteracting age-related declines in NAD⁺ levels. Preliminary research shows promising benefits for energy metabolism, cognitive function, and overall cellular health. While further comprehensive, controlled clinical studies are needed to establish definitive efficacy, optimal dosing, and long-term safety. Individuals interested in NAD⁺ IV drip therapy should consult with healthcare professionals to weigh the advantages against any potential risks.

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